Dry, itchy and reactive skin needs more than moisture. It needs a skin barrier that holds on to water and nerve endings that calm down. We tested our new Soothing Neurocosmetic Cream in a clinical study on 20 people with sensitive and atopic skin, and the results surprised even us: skin hydration increased in every participant after just one day, and redness from irritation calmed 3 times faster than on the untreated control area.
The Clinical Study in Brief
The study was carried out by the independent research institute Bionos in 2026. Twenty participants, 15 women and 5 men aged 17 to 71, used the cream daily for 28 days. All of them had sensitive and atopic skin. Skin hydration, transepidermal water loss (TEWL) and skin flaking were measured with instruments, and the calming effect was tested with an irritation test against an untreated control area.
Skin Hydration Increased in Every Participant
After one day of use, skin hydration had increased in all participants. After 28 days, hydration was still above the starting level in 95% of participants. On average, hydration increased by 28% after one day and by 31% after 28 days. The best single results were 100% more hydration after one day and 84% more after 28 days.
A Stronger Skin Barrier Means Less Water Loss
When the skin barrier is weak, water escapes through the skin and your skin dries out, tightens and reacts more easily. In 28 days, the cream reduced transepidermal water loss by 10% on average, a statistically significant change and a sign that the skin barrier works better. Water loss decreased in 85% of participants, and the best single result was 50% less water loss.
Less Flaking in 28 Days
Dry, atopic skin often flakes. Skin flaking decreased by 9% on average in 28 days, which was also statistically significant. Flaking decreased in 70% of participants, and the best single result was 49% less flaking.
Irritated Skin Calmed 3 Times Faster
In the irritation test, the skin was first irritated in a controlled way, and the redness was then measured on the treated area and on an untreated control area. On the area treated with the cream, redness decreased from the starting level by 6% in 10 minutes, 11% in 30 minutes, 17% in 60 minutes and 26% in 90 minutes.
Compared with the control area, redness calmed 3 times faster at 10 minutes and almost 4 times faster at 30 minutes. For you, this means that the cream starts to calm irritated skin within minutes, not days.
How the Participants Felt About Their Skin
After four weeks, the participants assessed their own skin:
- 95% felt less redness
- 95% felt less itching
- 90% felt their skin was softer
- 85% felt less irritation
- 85% felt less dryness
- 85% felt their skin was smoother
- 75% felt they had fewer impurities
- 70% felt their skin was more elastic
95% liked how the cream felt on their skin, 85% liked its scent, 80% liked its texture and 70% said it absorbed well.
The cream was also tested in a separate four week consumer study. READ: Calming Itchy, Dry Skin Through the Nerve Endings: Soothing Neurocosmetic Cream Consumer Study Results
Why I Developed This Cream
I have lived with atopic eczema since I was a small child, and it is what made me develop our very first skincare products. I know how it feels when your skin itches at night, stings after a shower and reacts to almost everything. The Soothing Neurocosmetic Cream continues that work. We developed it from start to finish in our own laboratory in Perniö, Finland, for dry, itchy and reactive skin, and we make it in our own factory.
How the Cream Works
Itching starts in the nerve endings of the skin. When the skin barrier is weak, irritants reach those nerve endings more easily, and the skin answers with itching, stinging and redness. Neurocosmetics is skincare that works with this connection between the skin and its nerve endings.
The cream combines two soothing actives. One is inspired by the avenanthramides found in oats, which are known for calming itchy skin. The other is a polypore mushroom extract rich in grifolin, which calms reactive skin. Alongside them, shea butter and squalane replenish the lipids of your skin barrier, glycerin and betaine bind moisture, and allantoin soothes sensitive skin. Our own bladderwrack actives from the Bothnian Sea, Fucus DuoActive® and Fucus Fusion®, support the skin's own balance.
Explore the Soothing Neurocosmetic Cream in our shop.
Frequently Asked Questions
Is the Soothing Neurocosmetic Cream suitable for atopic skin?
Yes. The cream was developed for dry, itchy and reactive skin, and all participants in the clinical study had sensitive and atopic skin.
Where can I use the cream?
You can use it on your face, neck and body, including skin folds.
Does the cream contain fragrance?
No. The Soothing Neurocosmetic Cream is fragrance free.
How quickly will I notice a difference?
In the clinical study, skin hydration increased in every participant after one day, and redness from irritation started to calm within 10 minutes. In our consumer study, 65% noticed a change within a week.
*Clinical study, Bionos 2026: 20 participants with sensitive and atopic skin, 28 days of use.